Wheat is the most significant grain crop in the world as well as in Bangladesh. It ranked second to the country in terms of consumption while third for production. Only one-fourth of its demand was produced by the country and which was around 12.37 lakh metric tons from 3.40 lakh ha areas during the 2020-21 crop season. Around 23 different diseases have been identified on wheat in Bangladesh and of which leaf rust caused by a fungal pathogen Puccinia triticina is an important disease and causes significant losses of yield (10-35%) if the susceptible variety is grown under late seeding conditions and the infection begins at the beginning of the booting stage. Most commonly it occurs in the 3rd week of February in Bangladesh’s agro-climatic conditions. Intensive disease surveillance and monitoring program regularly organized by Bangladesh Wheat and Maize Research Institute (BWMRI) in major wheat-growing areas of Bangladesh to know the current status of leaf rust and response on cultivated varieties to the disease. The distribution of disease was uneven and infrequent. Timely (15-30 November) sown fields have largely escaped the disease compared to late-planted crops. The number of leaf rust infected fields was more in the north-western part than in other parts of the country. Varying levels of disease severity with several types of reaction were observed in different varieties. Among the varieties surveyed, the predominant variety Prodip demonstrated zero to high degrees of disease severity with susceptible type of reactions whereas the variety BARI Gom 26 having the gene Lr34 source of effective durable resistance to leaf rust found with similar degrees of disease severity with moderately susceptible to susceptible reactions. The varieties BARI Gom 33, BARI Gom 30, BARI Gom 29, BARI Gom 28, and BARI Gom 25 displayed zero to low levels of disease severity with moderately susceptible to susceptible reaction. The newly released variety WMRI Gom 3 and one older variety Shatabdi were found free from leaf rust infection. The survey results demonstrated that most of the cultivated varieties showed moderately susceptible (MS) to susceptible (S) reactions, which indicated that most of our varieties are vulnerable to the disease. On the other hand, an experiment was conducted in BWMRI to evaluate the efficacy of some chemical fungicides against the disease. Six fungicides having Propiconazole, Tebuconazole, a combination of Propiconazole with Difenoconazole, a combination of Azoxystrobin and Difenoconazole, Hexaconazole, and a combination of Tebuconazole with Trifloxystrobin were tested against the disease under field conditions with a susceptible variety Prodip and found , all the fungicides were effective to control the disease (99-100%) with significant yield increase. Therefore, it can be concluded that by applying fungicide in time farmers may be able to cultivate susceptible variety under field conditions.